Dahlan Siahaan, Burhanuddin Nasution, Nizam Zikri Akbar


Background: Coronary heart disease (CHD) is a cumulation of plaque in the heart arteries that can
cause heart attacks. CHD is one of the main and rst causes of death in developed and developing
countries, including Indonesia. It is estimated that throughout the world, CHD in 2020 became the rst most frequent killer of
36% of all deaths, twice as high as cancer deaths. Currently Gamma Glutamyl Transferase (GGT) is a prognostic marker of
death and reinfarction in patients with patients Coronary Artery Disease (CAD) and there is a relationship of GGT with the
prognosis of CAD patients undergoing angiography.
Methods: The study was conducted by cross sectional method. The study subjects were 60 male and female CHD patients who
were treated and treated at the hospital in the Department of Cardiology FK-USU / H. Adam Malik Hospital Medan, which was
enforced by history, physical examination, angiography and laboratory and underwent coronary angiography. GGT
examination uses Architect c8000.
Results: A total of 60 CHD patients in this study found that GGT values were greater in the ≥70% group compared with
occlusions <70% with p = 0.003.
Conclusions: This study showed a signicant difference in the values of GGT with occlusion ≥70% and <70% occlusion.

Full Text:



Guff DC Jr et al, 2013. American Heart Assocciation. Guideline on the Assessment of Cardiovascular Risk.

Hastriadi P. 2011. Hubungan kepatuhan diit dengan kadar kolesterol penderit PJK. Universitas Muhammadiyah Semarang.

Riskesdas 2013, Badan penelitian dan Pengembangan kesehatan Departemen Kesehatan Republik Indonesia: Desember 2013.

Yahya AF. 2010. Menaklukkan pembunuh no 1: Mencegah dan mengatasi penyakit jantung coroner secara tepat. PT. Mizan Pustaka , Bandung.

Ndrepepa G, Kastrati A. 2016. Gamma-gluramyl transferase and cardiovascular disease. Annals of translation medicine 2016;4 (24):481.

Fornaciari I, et al. 2014. ϫ-glutamyl transferase fractions in human plasma and bile characteristic and biogenesis. Plos One 2014;9:e88532.

Foyer CH, Noctor G. 2005. Redox hemostasis and antioxidant signaling: a metabolic interface between stress perception and physiological respons. Plant Cell 2005;17:1866-75.

Mesinger C, Doring A, Schneider A. 2006. Serum ϫ-glutamyl transferase is a predictor of incident coronary events in apparently healthy men from the general population. J. atherosclerosis. 2006;297-302.

Paolichi A, et al. 2005. Beta lipoprotein and LDL –associated serum gamma glutamil transferase in patients with coronary atherosclerosis. Atherosclerosis, 2005: Aug17.

Bulusu S, Sharma M. What does serum ϫ-glutamyl transferase tell us a cardiometabolic risk marker ? Ann Clin Biochem 2016;53:312-32.

Lee DH, et al. 2006. Serum ϫ-glutamyl transferase predicts non fatal myocardial infarction and fatal coronary heart disease among 28 middle aged men and women. Eur Heart J 2006;27:2170-6.

Sabri Demircan, MD et al 2009. The Importance of Gamma Glutamyltransferase Activity in Patients with Coronary Artery Disease. Clin. Cardiol. 2009 ; 32, 4, 220 – 225.

Arsalan Majeed Adam et al 2017. Prevalence of Convensional Risk Factors and Evaluation of Baseline Incidies Among Young and Elderly Patients with Coronary Artery Disease 2017, vol-11(7) : oc34 – oc39.

Siavash Arasteh et al. 2018. Serum level of gamma glutamyl transferase as a biomarker for predicting stenosis severity in patients with coronary artery disease. Indian Heart Journal 2018 : 70 : 788-792.

Vani Bharani et al. 2017. Evaluation of gamma glutamyl transferase as a marker of cardiovascular risk, in 200 angiographically proven coronary artery disease patients 2017: Indian Heart Journal 69 (2017): 325 – 327.

Mason JE, Starke RD, Van Kirk JE. ϫ-glutamyl transferase: a novel cardiovascular risk biomarker. Prev Cardiol 2010;13:36-41.

Atar Al et al, 2013. Association between gamma-glutamyl transferase and coronary artery calcification. Int J Caediol 2013; 167: 1264-1267.

Theodor Baars et al. 2016. In acut myocardial infarction liver parameters are associated with stenosis diameters 2016 : Feb : vol 95 number 6.


  • There are currently no refbacks.