Saiful Hendra Romadon, Achsanuddin Hanae, Ratna Akbari Ganie


Background: Sepsis is still a global health problem because the mortality rate is quite high. There are
many markers being evaluated to assess the severity of sepsis, including IL-18. The purpose of this study
is to nd out whether IL-18 levels can be used as a predictor of severity in sepsis patients associated with SOFA scores.
Methods: Design of this study was a prospective cohort. 42 patients with sepsis who were treated in ICU H. Adam Malik Medan
Hospital who met the inclusion criteria were included in this study. Samples were examined for IL-18 for the rst day and the third
day, as well as SOFA scores for the rst day and the third day.
Results and Discussion: The rst day level of IL-18 had a signicans relationship with the rst day of SOFA score (p<0.05) and
the third day level of IL-18 had a signicans relationship with the third day of SOFA score (p<0.05).
Conclusions: IL-18 levels can be used as an alternative parameter to assess the severity in sepsis patients in addition to the
SOFA Score

Full Text:



Michelle, V, Fernanda Bordignon Nunes, Leonardo Pedrazza, Gabriela Caeran, Giovana Pellegrin, Denizar A.S. Melo, et al. 2016. Biochemical and inflammatory aspects in patients with severe sepsis and septic shock: The predictive role of IL-18 in mortality. Clinica Chimica Acta 2016; 453: 100–106.

Singer, M. et al., 2016. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(February), pp.801 - 810.

Duncan McPherson,1,2 Clare Griffiths,3 Matthew Williams,2 Allan Baker,3 Ed Klodawski,3 Bobbie Jacobson,3 Liam Donaldson Sepsis-associated mortality in England: an analysis of multiple cause of death data from 2001 to 2010 McPherson D.

Aftab H, Sachin P, Alexis LP, Ronald SC. 2013. The Simplified Acute Physiology Score III Is Superior to the Simplified Acute Physiology Score II and Acute Physiology and Chronic Health Evaluation II in Predicting Surgical and ICU Mortality in the ‘‘Oldest Old’’. Hindawi Publishing Corporation Current Gerontology and Geriatrics Research Volume 2014. pp. 1- 9

Keputusan Menteri Kesehatan Republik Indonesia Nomor 1778/MENKES/SK/XII/2010. Pedoman Penyelenggaraan Pelayanan Intensive Care Unit (ICU) di Rumah Sakit.

Vincent JL SY, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2014;34(2):344-53.

Ho KM, Lee KY, Dobb GJ, Webb SA. C-reactive protein concentration as a predictor of in-hospital mortality after ICU discharge: a prospective cohort study. Intensive care medicine. 2012; 34(3):481– 487.

Nolan KF, Greaves DR, Waldmann H (July 2012). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci". Genomics. 51 (1): 161–3.

Wang L, Zhao H and Wang D. Inflammatory cytokine expression in patients with sepsis at an intensive care unit. Experimental And Therapeutic Medicine 16: 2126-2131, 2018

Gao H, Evans WT and Finney SJ. Bench-to-bedside review: Sepsis, severe sepsis and septic shock – does the nature of the infecting organism matter? Critical Care 2008, 12:213.

Jordan AK Greg SM. The Changing Epidemiology and Definitions of Sepsis. Clin Chest Med. 2016 June ; 37(2): 165–179.

LaRosa, dan Steven P., 2010. Sepsis, Practice Based Pharmacology, Cleveland Clinic.Availablefrom: diseasemanagement/infectious-disease/sepsis/.

Yang Y, Xie J, Guo F, Longhini F, Gao Z, Huang Y, et al. 2016. Combination of C-reactive protein, procalcitonin and sepsis-related organ failure score for the diagnosis of sepsis in critical patients.Ann Intensive Care, 6: 51.


  • There are currently no refbacks.