ASSESSMENT OF SERUM TOTAL SIALIC ACID AND LIPID BOUND SIALIC ACID LEVELS IN PATIENTS WITH LEUKOPLAKIA AND ORAL SQUAMOUS CELL CARCINOMA-A CASE CONTROL STUDY

Dr Daneshwari Koshti, Dr Arvind Shetti, Dr Anjana Bagewadi, Dr Anuradha Patil

Abstract


Background and objectives: Oral cancer (OC) is the eleventh most common cancer worldwide. The reason for high prevalence of Oral cancer in
India is primarily attributed to tobacco consumption in the form of gutkha, quid, snuff or misri. The most common diagnostic method is biopsy
followed by analysis of serum and saliva that are an effective approach for screening and monitoring the patients. Tumor markers are substances
which change quantitatively in serum during tumor development. Various tumor markers are identified in oral cancer, one such tumor marker is
sialic acid. The objective of the study was to evaluate clinical value of circulatory levels of total and lipid bound sialic acid for the early diagnosis
and management of OC.
Method: A total of 90 patients were included in the study were further divided into three groups with 30 subjects each. Group 1 - leukoplakia.
Group 2- oral squamous cell carcinoma(OSCC). Group 3- healthy age and sex matched individuals. All the three groups were subjected to
determination of Serum total and lipid bound sialic acid. Statistical analysis was done using Student t- test, One way ANOVA was used to compare
between the three groups. Multi variate analysis was performed to determine the alterations in TSA and LSA levels. Results
Mean value of serum TSA in Group 1 - 53.18±9.03 mg/dl ,Group 2 -91.58±19.26 mg/dl Group 3 -36.74±5.94 mg/dl.
Mean value of serum LSA in Group 1-19.50±3.87 mg/dl , Group 2-33.64±8.05mg/dl, Group 3-14.10±2.86 mg/dl
Mean value of serum TSA and LSA in OSCC were significantly higher than leukoplakia and control group (P=0.0001). When multivariate analysis
was done it was observed that there is progressive rise in TSA and LSA
Conclusion: In the present study there were significant elevations in sialic acid levels in OSCC. This finding can be used as adjunct diagnostic
marker in head and neck cancer


Full Text:

PDF

References


National Oral Cancer Registry 2012, viewed 24 September 2013, http://www.nocr.org.in/oral cancer/incidence.aspx.

Nathaneal I Berlin .Tumor marker in cancer prevention and detection. Cancer 1981; 47:1151-1153.

Goodzari MT, Shafiei M, Nomani H, Shahriarahmadi A. Relationship between Total and lipid bound serum sialic acid and some tumours markers . Iran J of Med Sci.2005;30 (3):124-127.

Vasanti R.Rao, Ph.D, Lakshmi Krishnamoorthy, Ph.D., S.V.Kumaraswamy, M.D.S and Girija Ramaswamy, Ph.D. “Cancer Detection and Prevention,22(3):237-240(1998).

Dadhich M, Prabhu V, Pai VR, D«SQ»Souza J, Harish S, Jose M. Serum and salivary sialic acid as a biomarker in oral potentially malignant disorders and oral cancer. Indian J Cancer 2014;51:214-8

Pervin vural, Mukaddes canbaz , Dilek selçuki, Total and Lipid–Bound Sialic Acid Levels in Actinic Keratosis and Basal Cell Carcinoma. Tr. J. of Medical Sciences 29 (1999) 419-423

Sasaki.T, MolesD.R, Imai.Y, P. M. Speight.P.M. “Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age”. J Oral Pathol Med (2005) 34: 129–33.

Tu Ngoc Tran, Yenchun Liu, Minoru Takagi, Akira Yamaguchi, Hiroaki Fujii. “Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel-associated oral carcinoma in a Vietnamese non-smoking/non-drinking female population”. J Oral Pathol Med (2005) 34: 150–6.

Takashi Hase, Shuichi Kawashiri, Akira Tanaka, Shinichi Nozaki. “Correlation of basic fibroblast growth factor expression with the invasion and the prognosis of oral squamous cell carcinoma”. J Oral Pathol Med (2006) 35: 136–9.

Van Der Waal, T. Axell . Review Oral Leukoplakia: a proposal for uniform reporting. Oral Oncology 38 (2002) 521-526

Markopaulos AK, Michailidou EZ, Tzimagiogis G. Salivary markers for Oral Cancer Detection. The Open dentistry Journal. 2010;4:172-178

Ralhan Ranju.Diagnostic Potential of Genomic and Proteomic signatures in Oral cancer. Int J Hum Genet. 2007;7(1) 57-66.

Sanjay Reddy B, Madhavi Reddy B, Shyam NDVN. Tumor markers in Oral Neoplasia. IJDA 2010:2(1);103

Rajpura KB , Patel PS, Chawda JG , Shah RM. Clinical significance of total and lipid bound sialic acid levels in oral pre-cancerous conditions and oral cancer. J Oral Pathology Med 2005;34:263-7.

Syed Taqi. Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer.Indian Journal of Medical and Paediatric Oncology;Jan-mar2012:Vol33-issue1

Joshi M, Patil R. Estimation and comparative study of serum total sialic acid levels as tumor markers in oral cancer and precancer .J Cancer Research ther 2010;6:263-6.

Kaushik Patolia1, Maitri Shah, An Assessment of Serum Total Sialic Acid in Oral Leukoplakia and Oral Squamous Cell Carcinoma at Nadiad, Gujarat. International Journal of Medical Pediatrics and Oncology, April-June, 2016:2(2):56-59

Eliza Carla Barroso Duarte, Marina Sena Lopes Da Silva, Marcus Vinicius Gomez, Ricardo Santiago Gomez. “GSTM1 polymorphism and oral Leukoplakia”. J Oral Pathol Med (2006) 35: 202–5.

S. Warnakulasuriya1, Newell. W. Johnson2, I. van der Waal. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med (2007) 36: 575–80

Sankaranarayanan R. Oral cancer in India: An epidemiologic and clinical review. Oral Surg Oral Med Oral Pathol. 1990;69:325-30.

Jatin k. Nagpal, srinivas patnaik and bibhu r. Das. Prevalence of high-risk human papilloma virus types and its Association with p53 codon 72 polymorphism in tobacco

Achalli S, Madi M, Babu SG, Shetty SR, Kumari S, Bhat S. Sialic acid as a biomarker of oral potentially malignant disorders and oral cancer. Indian J Dent Res 2017;28:395-9.

Shashikant MC, Balajirao. Study of serum fucose and serum sialic acid levels in oral squamous cell carcinoma. Indian J Dent Res 1994;5:117-24.

Bina R baxi, Prabhudas Patel, Siddharth G, Adhvaryu and Pramod K Dayal.Usefulness of serum glycoconjugates in precancerous and cancerous diseases of the oral cavity. Cancer 1991;67:135-140

Karthik Krishnan and Sivapathasundharam Balasundaram, Sialic Acid a Prognostic Marker in Premalignancy Journal of Clinical and Diagnostic Research. 2017 Mar, Vol-11(3): ZC25-ZC


Refbacks

  • There are currently no refbacks.