Dr. A. Vijayalakshmi, Dr.s. Malliga


Cirrhosis can occur as result of various chronic hepatic disease and the incidence of hepatocellular carcinoma arising from cirrhosis is also variable
depending on the etiology resulting cirrhosis. Viral hepatitis and alcohol consumption are the most world-wide among the most common causes of
HCC.we planned this study to nd out the the clinicopathological correlation in chronic liver disease and HCC. This study was done after obtaining
the approval from Institutional Human Ethical Committee (IHEC) of Govt. Stanley Medical College, Chennai. 65 liver specimens were taken for
this study. Hematoxylin and eosin staining of sections were done. Histopathological examinations of these sections were done. The cases showed
an age range from 15 to 73 years. The cases with normal liver histology in the age ranges 15 to 35 years, hepatitis ranges 19 to 51, cirrhosis ranges 15
t0 73 years and the HCC ranges 34-73 years. 45 cases were males and 16 were females.Amongst 8 cases of hepatitis, 4(50%) were males and
4(50%) were females. Amongst 17 cases of cirrhosis, 12(71%) were males and 5(29%) were females. Amongst 30 cases of HCC, 25(83%) were
males and 5(17%) were females. chronic alcohol intake history was found in 50% of hepatitis patients, 63% of cirrhosis patients and 83% of HCC
patients. In this study the most common risk factor for HCC is chronic alcohol intake followed by viral hepatitis.the signicance of the
development of hepatocellular carcinoma in the background of chronic hepatocellular injury has been highlighted.

Full Text:



Park YN, Kim YB, Yang KM, Park C. Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 2000; 124: 1061–1065

Linderholm BK, Lindh B, Beckman L, Erlanson M, Edin K, Travelin B, Bergh J, Grankvist K, Henriksson R. Prognostic correlation of basic fibroblast growth factor and vascular endothelial growth factor in 1 307 primary breast cancers. Clin Breast Cancer 2003; 4: 340–347

Folkman J, Shing Y. Seminars in Medicine of the Beth Israel Hospital, Boston. Angiogenesis. J Biol Chem 1992; 267: 10931–10934

Folkman J. Clinical applications of research on angiogenesis. N Engl J Med 1995; 333: 1757–1763

Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306–1309

Mise M, Arii S, Higashituji H, Furutani M, Niwano M, Harada T, Ishigami S, Toda Y, Nakayama H, Fukumoto M, Fujita J, Imamura M. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996; 23: 455–464

Inoue K, Ozeki Y, Suganuma T, Sugiura Y, Tanaka S. Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer 1997; 79: 206–213

Ishigami SI, Arii S, Furutani M, Niwano M, Harada T, Mizumoto M, Mori A, Onodera H, Imamura M. Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br J Cancer 1998; 78: 1379–1384

Yoshiji H, Kuriyama S, Yoshii J, Ikenaka Y, Noguchi R, Hicklin DJ, Wu Y, Yanase K, Namisaki T, Yamazaki M, Tsujinoue H, Imazu H, Masaki T, Fukui H. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut 2003; 52: 1347–1354

Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, Housset C, Rosmorduc O. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology


  • There are currently no refbacks.