Anjana jose, J. K. Mukkadan, Manju kamal


Diabetes mellitus (DM) has emerged as a major public health problem in India. Diabetic nephropathy have higher prevalence of thyroid disorder
when compared with diabetes mellitus. The present study compared the levels of thyroid hormones between type 2 diabetes mellitus with and
without diabetic nephropathy. Among 192 diabetes mellitus patients those who have nephropathy, euthyroid was 124(64.6%), low T3 was
14(7.3%), subclinical hypothyroidism was 36(18.8%) and overt hypothyroidism was 18(9.4%) and other 192 patients those who haven't
nephropathy, euthyroid was 159(82.8%), low T3 was 7(3.6%), subclinical hypothyroidism was 11(5.7%) and overt hypothyroidism was 15(7.8%).
We found a statistically signicant correlation between TSH and urine protein creatinine ratio (urine PCR). Routine assessment of thyroid
hormones in patients will help to improve general wellbeing and reduce the mortality risk.

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Singh G, Gupta V, Sharma AK, Gupta N. Frequency of thyroid dysfunction among diabetes in Punjabi population. Adv.Biores. 2011; 2 : 3-9.

Iglesias, P. & Diez, J.J.Thyroid dysfunction and kidney disease. European journal of endocrinology. 2009 ; 160: 503-515.

Zhang, Chang Y, Ryu S, Thyroid hormone levels and incident chronic kidney disease in euthyroid individuals: the kangbuk Samsung Health Study.International journal of epidemiology. 2014 ; 43: 1624-1632.

Gu, Y, Li H, Bao X, The Relationship between Thyroid function and the prevalence Of Type 2 Diabetes mellitus in Euthyroid Subjects. The Journal of Clinical endocrinology and metabolism. 2017 ;102: 434-442.

Chubba SA, Davis WA, Inman Z Prevalence and progression of a subclinical hypothyroidism in women with Type 2 Diabetes: the Fremantle Diabetes study.Cli Endocrinol(oxf). 2005; 62(4): 480-486.

Mansournia M , Riyahi S, Heidari Z Subclinical hypothyroidism and diabetic nephropathy in Iranian patients with type 2 diabetes. J Endocrinol Invest. 2016;40(3):289-295.

Srinidhi Rai, Ashok Kumar J, Prajna K Thyroid function in Type 2 diabetes mellitus and in diabetic nephropathy. Journal of Clinical and Diagnostic Research. 2013 ;7(8): 1583-1585.

Chen HS, Wu TEJ, Jap TS Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients. Diabetic Medicine. 2007 ;24: 1336-1344.


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