A STUDY ON IV LABETALOL VERSUS ORAL NIFEDIPINE IN ACUTE CONTROL OF SEVERE HYPERTENSION IN PREGNANCY

Dr. G. Kesava Chandra, Dr. Sireesha Ratala

Abstract


Objective: To compare the efficacy of IV Labetalol with oral Nifedipine in the treatment of severe hypertension in
pregnancy with blood pressure >160/110mm Hg.
Methods: A parallel double blinded randomized control trial between Jan 2019 and May 2019 in 100 antenatal women of
gestational age>28 weeks, admitted with blood pressure >160/110 mm Hg conducted in labour ward tertiary hospital.
Antenatal women were randomized to receive oral Nifedipine 10mg tablet orally up to 5 doses and IV Labetalol was
initiated at 20mg and in escalating doses of 20mg, 40mg.80mg, and 80mg up to 220mg. The number of doses and
meantime taken to achieve target blood pressure <140/90 mm Hg was noted.
Results: hundred antenatal women were randomized to 50 in each group. In the Labetalol group 5 patients required oral
Nifedipine to achieve target blood pressure but none in the Nifedipine group. The numbers of doses required and
meantime taken to achieve target bloodpressure in nefidipine group were less compared to that of Labetalol group.
Conclusion: IV Labetalol and oral Nifedipine were equally effectively to achieve target blood pressure. Incomparsion,
oral Nifedipine achieved target blood pressure more quickly than Labetalol.


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References


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